Article
Blunted renal vascular response to angiotensin II is associated with a common variant of the angiotensinogen gene and obesity.
Journal of hypertension - 1 Feb 1996
Hopkins P N, Lifton R P, Hollenberg N K, Jeunemaitre X, Hallouin M C, Skuppin J, Williams C S, Dluhy R G, Lalouel J M, Williams R R, Williams G H
Abstract excerpt
OBJECTIVE: Recently, we reported evidence for genetic linkage between human essential hypertension and the angiotensinogen gene (AGT) and an association with a common molecular variant of this gene (methionine 235 --> threonine or T235). Other studies had led us to hypothesize that blunted renal plasma flow responses to infused angiotensin II (Ang II) when in high salt balance may reflect increased intrarenal...
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