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Glycosylated Derivatives of Steffimycin: Insights into the Role of the Sugar Moieties for the Biological Activity

25 Jan 2008

Abstract excerpt

Expression of the steffimycin gene cluster in Steptomyces albus in combination with plasmids directing the biosynthesis of different neutral and branched-chain deoxyhexoses led to the identification of twelve new glycosylated derivatives of steffimycin with different degrees of decoration in the tetracyclic core. These experiments demonstrate the flexibility of L-rhamnosyltransferase StfG for recognition of a...

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PMID: 18224649
DOI: 10.1002/cbic.200700610

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