Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deoxysugar Methylation during Biosynthesis of the Antitumor Polyketide Elloramycin by Streptomyces olivaceus

1 Jun 2001

Abstract excerpt

The anthracycline-like polyketide drug elloramycin is produced by Streptomyces olivaceus Tü2353. Elloramycin has antibacterial activity against Gram-positive bacteria and also exhibits antitumor activity. From a cosmid clone (cos16F4) containing part of the elloramycin biosynthesis gene cluster, three genes (elmMI, elmMII, and elmMIII) have been cloned. Sequence analysis and data base comparison showed that their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Microbial Natural Products and Biosynthesis
Share to Plant Disease Resistance and Genetics
Share to Plant-Microbe Interactions and Immunity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 11376004
DOI: 10.1074/jbc.m101225200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deoxysugar Methylation during Biosynthesis of the Antitumor Polyketide Elloramycin by Streptomyces olivaceusPMID 11376004Read ↗

Glycosylated Derivatives of Steffimycin: Insights into the Role of the Sugar Moieties for the Biological ActivitySemantic proximity Read ↗

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic PathwaySemantic proximity Read ↗

Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic WindowSemantic proximity Read ↗

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.Semantic proximity Read ↗

Metabolic engineering of Streptomyces peucetius for biosynthesis of N,N-dimethylated anthracyclinesSemantic proximity Read ↗

New Sipanmycin Analogues Generated by Combinatorial Biosynthesis and Mutasynthesis Approaches Relying on the Substrate Flexibility of Key Enzymes in the Biosynthetic Pathway.Semantic proximity Read ↗

One-Pot Combinatorial Biosynthesis of Glycosylated Anthracyclines by Cocultivation of Streptomyces Strains Producing Aglycones and Nucleotide Deoxysugars.Semantic proximity Read ↗

Analysis of the loading and hydroxylation steps in lankamycin biosynthesis in Streptomyces rochei.Semantic proximity Read ↗

Enhancement of bleomycin production in Streptomyces verticillus through global metabolic regulation of N-acetylglucosamine and assisted metabolic profiling analysisSemantic proximity Read ↗

Production of the antitumor drug epirubicin (4'-epidoxorubicin) and its precursor by a genetically engineered strain of Streptomyces peucetius.Semantic proximity Read ↗

A gene cluster from Streptomyces galilaeus involved in glycosylation of aclarubicin.Semantic proximity Read ↗

Characterization of two glycosyltransferases involved in early glycosylation steps during biosynthesis of the antitumor polyketide mithramycin by Streptomyces argillaceus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.