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Article

The effect of small molecules in modulating the chaperone activity of alphaB-crystallin against ordered and disordered protein aggregation.

The FEBS journal - 1 Mar 2008

Ecroyd Heath, Carver John A

Abstract excerpt

Protein aggregation can proceed via disordered or ordered mechanisms, with the latter being associated with amyloid fibril formation, which has been linked to a number of debilitating conditions including Alzheimer's, Parkinson's and Creutzfeldt-Jakob diseases. Small heat-shock proteins (sHsps), such as alphaB-crystallin, act as chaperones to prevent protein aggregation and are thought to play a key role in the...

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PMID: 18218039
DOI: 10.1111/j.1742-4658.2008.06257.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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