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Article

Deletion of Specific Conserved Motifs from the N-Terminal Domain of αB-Crystallin Results in the Activation of Chaperone Functions.

International journal of molecular sciences - 20 Jan 2022

Mahalingam Sundararajan, Shankar Goutham, Mooney Brian P, Singh Kamal, Santhoshkumar Puttur, Sharma Krishna K

Abstract excerpt

Smaller oligomeric chaperones of α-crystallins (αA- and αB-) have received increasing attention due to their improved therapeutic potential in preventing protein aggregating diseases. Our previous study suggested that deleting 54-61 residues from the N-terminal domain (NTD) of αB-crystallin (αBΔ54-61) decreases the oligomer size and increases the chaperone function. Several studies have also suggested that NTD...

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Identifiers

PMID: 35163023
DOI: 10.3390/ijms23031099
PMCID: PMC8834691

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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