Article
Cathepsin G, a leukocyte protease, activates coagulation factor VIII.
Thrombosis and haemostasis - 1 Jan 2008
Gale Andrew J, Rozenshteyn Diana
Abstract excerpt
Neutrophils and monocytes express cathepsin G and can also bind to activated platelets, thus they can be localized to the site of active coagulation. Previous studies have suggested that cathepsin G inactivated coagulation factor VIII (FVIII) and was thus anticoagulant. But other studies have indicated procoagulant functions for cathepsin G in activation of coagulation factor V or activation of platelets among...
Topics
- Blood Coagulation
- Cathepsin G
- Cathepsins
- Disulfides
- Factor VIII
- Factor VIIIa
- Humans
- In Vitro Techniques
- Mutation
- Neutrophils
- Partial Thromboplastin Time
- Recombinant Proteins