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Article

Quantum proteolysis by neutrophils: implications for pulmonary emphysema in alpha 1-antitrypsin deficiency.

The Journal of clinical investigation - 1 Aug 1999

Campbell E J, Campbell M A, Boukedes S S, Owen C A

Abstract excerpt

Traditional enzyme kinetics provide a poor explanation for the increased risk of lung injury in alpha 1-antitrypsin (AAT) deficiency. Millimolar concentrations of leukocyte elastase, when released from single azurophil granules of activated neutrophils, lead to evanescent quantum bursts of proteolytic activity before catalysis is quenched by pericellular inhibitors. Herein, we tested the possibility that quantum...

Topics

Cytoplasmic Granules
Endopeptidases
Humans
Hydrolysis
Inflammation Mediators
Isoelectric Focusing
Models, Biological
Neutrophil Activation
Neutrophils
Phenotype
Pulmonary Emphysema

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Quantum Theory

alpha 1-Antitrypsin

alpha 1-Antitrypsin Deficiency

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Identifiers

PMID: 10430615
DOI: 10.1172/JCI6092
PMCID: PMC408416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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