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Article

Genomewide expression analysis in zebrafish mind bomb alleles with pancreas defects of different severity identifies putative Notch responsive genes.

PloS one - 23 Jan 2008

Hegde Ashok, Qiu Nick Chuanxin, Qiu Xuehui, Ho Steven Hao-Kee, Tay Kenny Qi-Ye, George Joshy, Ng Felicia Soo Lee, Govindarajan Kunde Ramamoorthy, Gong Zhiyuan, Mathavan Sinnakaruppan, Jiang Yun-Jin

Abstract excerpt

BACKGROUND: Notch signaling is an evolutionarily conserved developmental pathway. Zebrafish mind bomb (mib) mutants carry mutations on mib gene, which encodes a RING E3 ligase required for Notch activation via Delta/Jagged ubiquitylation and internalization. METHODOLOGY/PRINCIPAL FINDINGS: We examined the mib mutants for defects in pancreas development using in situ hybridization and GFP expression analysis of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18213387
DOI: 10.1371/journal.pone.0001479
PMCID: PMC2195453

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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