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Article

Maternal and zygotic aldh1a2 activity is required for pancreas development in zebrafish.

PloS one - 11 Dec 2009

Alexa Kristen, Choe Seong-Kyu, Hirsch Nicolas, Etheridge Letitiah, Laver Elizabeth, Sagerström Charles G

Abstract excerpt

We have isolated and characterized a novel zebrafish pancreas mutant. Mutant embryos lack expression of isl1 and sst in the endocrine pancreas, but retain isl1 expression in the CNS. Non-endocrine endodermal gene expression is less affected in the mutant, with varying degrees of residual expression observed for pdx1, carbA, hhex, prox1, sid4, transferrin and ifabp. In addition, mutant embryos display a swollen...

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Identifiers

PMID: 20011517
DOI: 10.1371/journal.pone.0008261
PMCID: PMC2788244

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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