Article
Association of cumulative cyclosporine dose with its irreversible nephrotoxicity in Japanese patients with pediatric-onset autoimmune diseases.
Biological & pharmaceutical bulletin - 1 Dec 2007
Nakamura Tsutomu, Nozu Kandai, Iijima Kazumoto, Yoshikawa Norishige, Moriya Yuka, Yamamori Motohiro, Kako Asae, Matsuo Masafumi, Sakurai Aki, Okamura Noboru, Ishikawa Toshihisa, Okumura Katsuhiko, Sakaeda Toshiyuki
Abstract excerpt
Cyclosporine (CsA)-induced nephrotoxicity can become a major obstacle to continuous use. The aim of this study was to optimize CsA dose to avoid its irreversible nephrotoxicity. Twenty-three Japanese patients with pediatric-onset systemic lupus erythematosus or idiopathic nephrotic syndrome, who were maintained in a stable condition by oral dosing of CsA microemulsion, were enrolled in this study. The patients...
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