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Article

Mutation of C/EBPalpha predisposes to the development of myeloid leukemia in a retroviral insertional mutagenesis screen.

Blood - 15 Apr 2008

Hasemann Marie S, Damgaard Inge, Schuster Mikkel B, Theilgaard-Mönch Kim, Sørensen Annette B, Mrsic Alan, Krugers Thijs, Ylstra Bauke, Pedersen Finn S, Nerlov Claus, Porse Bo T

Abstract excerpt

The CCAAT enhancer binding protein alpha (C/EBPalpha) is an important myeloid tumor suppressor that is frequently mutated in human acute myeloid leukemia (AML). We have previously shown that mice homozygous for the E2F repression-deficient Cebpa(BRM2) allele develop nonfatal AML with long latency and incomplete penetrance, suggesting that accumulation of secondary mutations is necessary for disease progression....

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Identifiers

PMID: 18212247
DOI: 10.1182/blood-2007-06-097790

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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