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Article

Functional interactions of alcohol-sensitive sites in the N-methyl-D-aspartate receptor M3 and M4 domains.

The Journal of biological chemistry - 28 Mar 2008

Ren Hong, Salous Abdelghaffar K, Paul Jaclyn M, Lamb Kaitlin A, Dwyer Donard S, Peoples Robert W

Abstract excerpt

The N-methyl-D-aspartate receptor is an important mediator of the behavioral effects of ethanol in the central nervous system. Previous studies have demonstrated sites in the third and fourth membrane-associated (M) domains of the N-methyl-D-aspartate receptor NR2A subunit that influence alcohol sensitivity and ion channel gating. We investigated whether two of these sites, Phe-637 in M3 and Met-823 in M4,...

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Identifiers

PMID: 18208816
DOI: 10.1074/jbc.M705933200
PMCID: PMC2276391

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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