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Article

Mutations at F637 in the NMDA receptor NR2A subunit M3 domain influence agonist potency, ion channel gating and alcohol action.

British journal of pharmacology - 1 Jul 2007

Ren H, Salous A K, Paul J M, Lipsky R H, Peoples R W

Abstract excerpt

BACKGROUND AND PURPOSE: NMDA receptors are important molecular targets of ethanol action in the CNS. Previous studies have identified a site in membrane-associated domain 3 (M3) of the NR1 subunit and two sites in M4 of the NR2A subunit that influence alcohol action; the sites in NR2A M4 also regulate ion channel gating. The purpose of this study was to determine whether mutations at the site in the NR2A subunit...

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Source

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Identifiers

PMID: 17519952
DOI: 10.1038/sj.bjp.0707254
PMCID: PMC2014122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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