Article
A site of alcohol action in the fourth membrane-associated domain of the N-methyl-D-aspartate receptor.
The Journal of biological chemistry - 5 Dec 2003
Ren Hong, Honse Yumiko, Peoples Robert W
Abstract excerpt
The N-methyl-d-aspartate (NMDA) subtype of ionotropic glutamate receptor is an important mediator of the behavioral effects of ethanol in the central nervous system. Although ethanol is known to inhibit NMDA receptors by influencing ion-channel gating, its molecular site of action and the mechanism underlying this effect have not been established. We have previously identified a conserved methionine residue in...
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