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Article

Alcohols inhibit N-methyl-D-aspartate receptors via a site exposed to the extracellular environment.

Neuropharmacology - 24 Jul 2000

Peoples R W, Stewart R R

Abstract excerpt

N-Methyl-D-aspartate (NMDA) receptors are important CNS target sites of alcohols, but the site and mechanism of action of alcohols on NMDA receptors remains unclear. In CHO-K1 cells transfected with NR1/NR2B NMDA receptor subunits, ethanol inhibited NMDA-activated current with an IC(50) of 138 mM. Truncation of the intracellular C-terminal domain of the NR1 subunit (NR1T) did not alter ethanol sensitivity when...

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Identifiers

PMID: 10884550
DOI: 10.1016/s0028-3908(00)00067-8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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