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Article

Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling.

Experimental hematology - 1 Mar 2008

Mizutani Tatsuaki, Tsuji Kohichiro, Ebihara Yasuhiro, Taki Shinsuke, Ohba Yusuke, Taniguchi Tadatsugu, Honda Kenya

Abstract excerpt

OBJECTIVE: Erythrocyte production is tightly regulated by cytokines, particularly erythropoietin (EPO), which affects expansion and viability of erythroid lineage cells via induction of several factors, including Bcl2-like 1 (Bcl-XL). Because type I interferon (IFN) is known to inhibit erythropoiesis, we studied mice deficient in the gene for interferon regulatory factor 2 (IRF2), which functions as a negative...

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Source

Identifiers

PMID: 18207304
DOI: 10.1016/j.exphem.2007.11.004

Genes

EPO
IFNAR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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