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Article

Type I interferon differential therapy for erythroleukemia: specificity of STAT activation

17 Mar 2003

Abstract excerpt

Type I interferons (IFNs), pleiotropic cytokines with antiviral, antiproliferative, apoptotic, and immunoregulatory functions, are efficacious in the treatment of malignancies, viral infections, and autoimmune diseases. Binding of these cytokines to their cognate receptor leads to activation of the Jak-signal transducers and activators of transcription (STAT) signaling pathway and altered gene expression. This...

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PMID: 12446459
DOI: 10.1182/blood-2002-05-1521

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