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Article

Deficiency in interferon type 1 receptor improves definitive erythropoiesis in Klf1 null mice.

Cell death and differentiation - 1 Mar 2018

Manchinu Maria Francesca, Brancia Carla, Caria Cristian Antonio, Musu Ester, Porcu Susanna, Simbula Michela, Asunis Isadora, Perseu Lucia, Ristaldi Maria Serafina

Abstract excerpt

A key regulatory gene in definitive erythropoiesis is the transcription factor Krüppel-like factor 1 (Klf1). Klf1 null mice die in utero by day 15.5 (E15.5) due to impaired definitive erythropoiesis and severe anemia. Definitive erythropoiesis takes place in erythroblastic islands in mammals. Erythroblastic islands are formed by a central macrophage (Central Macrophage of Erythroblastic Island, CMEI) surrounded...

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Identifiers

PMID: 29230002
DOI: 10.1038/s41418-017-0003-5
PMCID: PMC5864211

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