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Article

Endoglin-mediated vascular remodeling: mechanisms underlying hereditary hemorrhagic telangiectasia.

Trends in cardiovascular medicine - 1 Jan 2008

Lebrin Franck, Mummery Christine L

Abstract excerpt

Endoglin is emerging as a pivotal component of the gateway for signaling by transforming growth factor-beta (TGF-beta) in vascular endothelial cells. Mutations in endoglin cause a rare vascular disorder in humans known as hereditary hemorrhagic telengiectasia (HHT). Although rare, in-depth analysis of mutant mice and mononuclear cells from the blood of patients with HHT have provided novel and exciting insights...

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Share to Antigens, CD
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Share to Intracellular Signaling Peptides and Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscle, Smooth, Vascular

Share to Neovascularization, Pathologic

Share to Receptors, Cell Surface

Share to Telangiectasia, Hereditary Hemorrhagic

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Source

Identifiers

PMID: 18206806
DOI: 10.1016/j.tcm.2007.11.003

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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