Article
Endoglin has a crucial role in blood cell-mediated vascular repair.
Circulation - 21 Nov 2006
van Laake Linda W, van den Driesche Sander, Post Simone, Feijen Alie, Jansen Maurits A, Driessens Mariette H, Mager Johannes J, Snijder Repke J, Westermann Cornelius J J, Doevendans Pieter A, van Echteld Cees J A, ten Dijke Peter, Arthur Helen M, Goumans Marie-José, Lebrin Franck, Mummery Christine L
Abstract excerpt
BACKGROUND: Endoglin, an accessory receptor for transforming growth factor-beta in vascular endothelial cells, is essential for angiogenesis during mouse development. Mutations in the human gene cause hereditary hemorrhagic telangiectasia type 1 (HHT1), a disease characterized by vascular malformations that increase with age. Although haploinsufficiency is the underlying cause of the disease, HHT1 individuals...
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