Article
Mouse model for hereditary hemorrhagic telangiectasia has a generalized vascular abnormality.
Circulation - 1 Apr 2003
Torsney Evelyn, Charlton Richard, Diamond Austin G, Burn John, Soames James V, Arthur Helen M
Abstract excerpt
BACKGROUND: Mutations in endoglin or activin like kinase-1, both involved in the endothelial transforming growth factor-beta signaling pathway, cause the autosomal dominant bleeding disorder hereditary hemorrhagic telangiectasia. We and others have reported mouse models for this disease that share the characteristic phenotype of dilated vessels and sporadic hemorrhage. The reasons for the variable phenotype in...
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