Article
Effect of peripheral obestatin on food intake and gastric emptying in ghrelin-knockout mice.
British journal of pharmacology - 1 Apr 2008
Depoortere I, Thijs T, Moechars D, De Smet B, Ver Donck L, Peeters T L
Abstract excerpt
BACKGROUND AND PURPOSE: The finding that obestatin, a peptide encoded by the ghrelin gene, opposes ghrelin's stimulatory effect on food intake and gastric emptying has been questioned. The effect of obestatin has been mostly investigated in fasted rodents, a condition associated with high blood levels of ghrelin which may mask the effect of obestatin. We therefore investigated the effect of obestatin on food...
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