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Article

Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome.

Pharmacogenomics - 1 Dec 2007

Le Morvan Valérie, Smith Denis, Laurand Armelle, Brouste Véronique, Bellott Ricardo, Soubeyran Isabelle, Mathoulin-Pelissier Simone, Robert Jacques

Abstract excerpt

INTRODUCTION: Glutathione S-transferase P1 (GSTP1) and excision-repair cross-complementing repair deficiency group 2 protein (ERCC2 or XPD) may modulate the activity of platinum derivatives. The SNPs, Ile105Val for GSTP1 and Lys751Gln for ERCC2, may affect the efficiency of oxaliplatin in patients treated with an oxaliplatin-based regimen for metastatic colorectal carcinoma. PATIENTS & METHODS: A total of 107...

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Identifiers

PMID: 18085999
DOI: 10.2217/14622416.8.12.1693

Genes

ERCC2
GSTP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Determination of ERCC2 Lys751Gln and GSTP1 Ile105Val gene polymorphisms in colorectal cancer patients: relationships with treatment outcome.PMID 18085999Read ↗

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