Article
Olig1 function is required to repress dlx1/2 and interneuron production in Mammalian brain.
Neuron - 5 Feb 2014
Silbereis John C, Nobuta Hiroko, Tsai Hui-Hsin, Heine Vivi M, McKinsey Gabriel L, Meijer Dimphna H, Howard Mackenzie A, Petryniak Magda A, Potter Gregory B, Alberta John A, Baraban Scott C, Stiles Charles D, Rubenstein John L R, Rowitch David H
Abstract excerpt
Abnormal GABAergic interneuron density, and imbalance of excitatory versus inhibitory tone, is thought to result in epilepsy, neurodevelopmental disorders, and psychiatric disease. Recent studies indicate that interneuron cortical density is determined primarily by the size of the precursor pool in the embryonic telencephalon. However, factors essential for regulating interneuron allocation from telencephalic...
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