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Article

SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer.

Human molecular genetics - 1 Apr 2008

Dong Xue-Yuan, Rodriguez Carmen, Guo Peng, Sun Xiaodong, Talbot Jeffrey T, Zhou Wei, Petros John, Li Qunna, Vessella Robert L, Kibel Adam S, Stevens Victoria L, Calle Eugenia E, Dong Jin-Tang

Abstract excerpt

Deletion of chromosome 6q14-q22 is common in multiple human cancers including prostate cancer, and chromosome 6 transferred into cancer cells induces senescence and reduces cell growth, tumorigenicity and metastasis, indicating the existence of one or more tumor-suppressor genes in 6q. To identif...

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Share to Chromosomes, Human, Pair 6
Share to Genes, Recessive

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Tumor Suppressor

Share to Germ-Line Mutation

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Share to Prostatic Neoplasms

Share to RNA, Small Nucleolar

Share to Sequence Deletion

Source

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Identifiers

PMID: 18202102
DOI: 10.1093/hmg/ddm375
PMCID: PMC2923223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18202102-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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