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Article

Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancer

11 Nov 2017

Abstract excerpt

// Martina Kluth 1, * , Simon Jung 1, * , Omar Habib 1 , Mina Eshagzaiy 1 , Anna Heinl 1 , Nina Amschler 1 , Sawinee Masser 1 , Malte Mader 1 , Frederic Runte 1 , Philipp Barow 1 , Sohall Frogh 1 , Jazan Omari 1 , Christina Möller-Koop 1 , Claudia Hube-Magg 1 , Joachim Weischenfeldt 2 , Jan Korbel 2 , Stefan Steurer 1 , Till Krech 1 , Hartwig Huland 3 , Markus Graefen 3 , Sarah Minner 1 , Guido Sauter 1 ,...

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PMID: 29312579
DOI: 10.18632/oncotarget.22408

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Deletion lengthening at chromosomes 6q and 16q targets multiple tumor suppressor genes and is associated with an increasingly poor prognosis in prostate cancerPMID 29312579Read ↗

Deletion of chromosomal region 6q14-16 in prostate cancer.Semantic proximity Read ↗

Concurrent deletion of 16q23 and PTEN is an independent prognostic feature in prostate cancerSemantic proximity Read ↗

Integration of high-resolution array comparative genomic hybridization analysis of chromosome 16q with expression array data refines common regions of loss at 16q23–qter and identifies underlying candidate tumor suppressor genes in prostate cancerSemantic proximity Read ↗

Clinical significance of chromosome 8p, 10q, and 16q deletions in prostate cancerSemantic proximity Read ↗

Genomic deletion of chromosome 12p is an independent prognostic marker in prostate cancerSemantic proximity Read ↗

Deletion of a small consensus region at 6q15, including the MAP3K7 gene, is significantly associated with high-grade prostate cancers.Semantic proximity Read ↗

Genetic mapping of allelic loss on chromosome 6q within heterogeneous prostate carcinoma.Semantic proximity Read ↗

KLF5 is frequently deleted and down-regulated but rarely mutated in prostate cancer.Semantic proximity Read ↗

SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer.Semantic proximity Read ↗

CHD1 is a 5q21 tumor suppressor required for ERG rearrangement in prostate cancer.Semantic proximity Read ↗

Review of allelic loss and gain in prostate cancer.Semantic proximity Read ↗

Three independently deleted regions at chromosome arm 16q in human prostate cancer: allelic loss at 16q24.1-q24.2 is associated with aggressive behaviour of the disease, recurrent growth, poor differentiation of the tumour and poor prognosis for the patient.Semantic proximity Read ↗

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