Article
Identification of ZDHHC14 as a novel human tumour suppressor gene.
The Journal of pathology - 1 Apr 2014
Yeste-Velasco Marc, Mao Xueying, Grose Richard, Kudahetti Sakunthala C, Lin Dongmei, Marzec Jacek, Vasiljević Natasa, Chaplin Tracy, Xue Liyan, Xu Maojia, Foster Julie M, Karnam Santi S, James Sharon Y, Chioni Athina-Myrto, Gould David, Lorincz Attila T, Oliver R Tim D, Chelala Claude, Thomas Gareth M, Shipley Janet M, Mather Stephen J, Berney Daniel M, Young Bryan D, Lu Yong-Jie
Abstract excerpt
Genomic changes affecting tumour suppressor genes are fundamental to cancer. We applied SNP array analysis to a panel of testicular germ cell tumours to search for novel tumour suppressor genes and identified a frequent small deletion on 6q25.3 affecting just one gene, ZDHHC14. The expression of ZDHHC14, a putative protein palmitoyltransferase with unknown cellular function, was decreased at both RNA and protein...
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