Article
Gap junction remodeling and cardiac arrhythmogenesis in a murine model of oculodentodigital dysplasia.
Proceedings of the National Academy of Sciences of the United States of America - 18 Dec 2007
Kalcheva Nellie, Qu Jiaxiang, Sandeep Nefthi, Garcia Luis, Zhang Jie, Wang Zhiyong, Lampe Paul D, Suadicani Sylvia O, Spray David C, Fishman Glenn I
Abstract excerpt
Gap junction channels are required for normal cardiac impulse propagation, and gap junction remodeling is associated with enhanced arrhythmic risk. Oculodentodigital dysplasia (ODDD) is a multisystem syndrome due to mutations in the connexin43 (Cx43) gap junction channel gene. To determine the effects of a human connexin channelopathy on cardiac electrophysiology and arrhythmogenesis, we generated a murine model...
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