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Article

Tfap2a and 2b act downstream of Ptf1a to promote amacrine cell differentiation during retinogenesis.

Molecular brain - 13 May 2015

Jin Kangxin, Jiang Haisong, Xiao Dongchang, Zou Min, Zhu Jun, Xiang Mengqing

Abstract excerpt

Retinogenesis is a precisely controlled developmental process during which different types of neurons and glial cells are generated under the influence of intrinsic and extrinsic factors. Three transcription factors, Foxn4, RORβ1 and their downstream effector Ptf1a, have been shown to be indispensable intrinsic regulators for the differentiation of amacrine and horizontal cells. At present, however, it is unclear...

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Identifiers

PMID: 25966682
DOI: 10.1186/s13041-015-0118-x
PMCID: PMC4429372

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