Article
Shared Genetics and Comorbid Genes of Amyotrophic Lateral Sclerosis and Parkinson's Disease.
Movement disorders : official journal of the Movement Disorder Society - 1 Oct 2023
Tian Ye, Ma Guochen, Li Haoqi, Zeng Yaxian, Zhou Siquan, Wang Xiaoyu, Shan Shufang, Xu Yujie, Xiong Jingyuan, Cheng Guo
Abstract excerpt
BACKGROUND: Comorbidity exists between amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD), but the role of genetic factors is unclear. OBJECTIVE: We aim to investigate genetic correlation, causal relationship, and comorbid genes between ALS and PD. METHODS: Leveraging the largest genome-wide association study data (ALS: 27,205 cases, 110,881 controls; PDG: 33,674 cases, 449,056 controls), we used...
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