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Pathway analysis of two amyotrophic lateral sclerosis GWAS highlights shared genetic signals with Alzheimer's disease and Parkinson's disease.

Molecular neurobiology - 1 Feb 2015

Shang Hong, Liu Guiyou, Jiang Yongshuai, Fu Jin, Zhang Benping, Song Rongrong, Wang Weizhi

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is the third most common neurodegenerative disease after Alzheimer's disease (AD) and Parkinson's disease (PD). In order to unravel more genetic etiology of ALS, genome-wide association studies (GWAS) have been conducted. However, the newly identified ALS susceptibility loci exert only very small risk effects and cannot fully explain the underlying ALS genetic risk. A large...

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PMID: 24647822
DOI: 10.1007/s12035-014-8673-1

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