Article
Effects of CCR2 and CCRS polymorphisms on HIV-1 infection in Thai females.
Journal of acquired immune deficiency syndromes (1999) - 1 Mar 2008
Wichukchinda Nuanjun, Nakayama Emi E, Rojanawiwat Archawin, Pathipvanich Panita, Auwanit Wattana, Vongsheree Suthon, Ariyoshi Koya, Sawanpanyalert Pathom, Shioda Tatsuo
Abstract excerpt
Polymorphisms in CCR2 and CCR5 genes reportedly affect HIV-1 transmission and disease progression in HIV-1-infected individuals. In the study presented here, we examined the effects of CCR2 and CCR5 polymorphisms on HIV-1 transmission in 74 Thai females who were exposed to HIV but seronegative (ESN) and in 347 HIV-seropositive females. We found that the combination of 2 non-synonymous substitutions, CCR2 V64I and...
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