Article
The genetic associations and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on susceptibility to HIV-1 infection in a Northern Han Chinese population.
Genetic testing and molecular biomarkers - 1 Dec 2012
Lu Jiapeng, Sheng Aijuan, Wang Youxin, Zhang Ling, Wu Jingjing, Song Manshu, He Yan, Yu Xinwei, Zhao Feifei, Liu Yezhou, Shao Shuang, Lan Jie, Wu Hao, Wang Wei
Abstract excerpt
The outcome of human immunodeficiency virus (HIV)-1 infection and course to AIDS are variable among individuals. Both chemokine receptor 5 (CCR5) and CCR2 gene polymorphisms play essential roles in the susceptibility of HIV-1 infection. To investigate the main and epistatic effects of the CCR5 promoter and CCR2-V64I polymorphisms on HIV-1 infection in the Northern Han Chinese, subjects of 91 HIV-1-infected...
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