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Article

SERT Ileu425Val in autism, Asperger syndrome and obsessive-compulsive disorder.

Psychiatric genetics - 1 Feb 2008

Wendland Jens R, DeGuzman Theresa B, McMahon Francis, Rudnick Gary, Detera-Wadleigh Sevilla D, Murphy Dennis L

Abstract excerpt

BACKGROUND: SERT I425V, an uncommon missense single nucleotide polymorphism producing a gain-of-function of the serotonin transporter (SERT), was originally found to segregate with a primarily obsessive-compulsive disorder (OCD) but complexly comorbid phenotype in two unrelated families. OBJECTIVE: As two individuals with SERT I425V and OCD also had Asperger syndrome (AS), an autism spectrum disorder, and as...

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Source

Identifiers

PMID: 18197083
DOI: 10.1097/YPG.0b013e3282f08a06

Genes

BDNF
COMT
GCH1
SGCE
SLITRK1
TPH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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