Polymorphisms of the methylenetetrahydrofolate reductase gene and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation.

doi:10.1007/s00277-006-0184-3

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Article

Polymorphisms of the methylenetetrahydrofolate reductase gene and clinical outcomes in HLA-matched sibling allogeneic hematopoietic stem cell transplantation.

Annals of hematology - 1 Jan 2007

Kim Inho, Lee Kyung-Hun, Kim Jin Hee, Ra Eun Kyung, Yoon Sung-Soo, Hong Yun-Chul, Park Sung Sup, Kim Chul Soo, Park Seonyang, Kim Byoung Kook

Abstract excerpt

To evaluate whether the C677T and A1298C polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) are related to the toxicity of methotrexate (MTX) used in allogeneic stem cell transplantation, we performed association analysis between these genetic polymorphisms and the clinical outcomes of patients treated using human leukocyte antigen-matched sibling stem cell transplantation. Patients (n=72) with...

Topics

Adolescent
Adult
Case-Control Studies
Female
Gene Frequency
Genotype
Hematopoietic Stem Cell Transplantation
Histocompatibility Testing
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Methylenetetrahydrofolate Reductase (NADPH2)

Middle Aged

Polymorphism, Single Nucleotide

Siblings

Survival Analysis

Transplantation, Homologous

Treatment Outcome

Source

Open in PubMed

Identifiers

PMID: 17028897
DOI: 10.1007/s00277-006-0184-3

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17028897-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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