Article
Pharmacogenetics of methotrexate: toxicity among marrow transplantation patients varies with the methylenetetrahydrofolate reductase C677T polymorphism.
Blood - 1 Jul 2001
Ulrich C M, Yasui Y, Storb R, Schubert M M, Wagner J L, Bigler J, Ariail K S, Keener C L, Li S, Liu H, Farin F M, Potter J D
Abstract excerpt
This study investigated whether a polymorphism in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene (C677T) modifies responses to methotrexate (MTX) in patients undergoing bone marrow transplantation. About 10% to 12% of the population carry the MTHFR TT genotype (enzyme activity, 30% of wild type [CC]). Patients (n = 220) with chronic myelogenous leukemia underwent marrow allografts and were given a...
Topics
- Adult
- Bilirubin
- Biotransformation
- Bone Marrow Transplantation
- Cohort Studies
- Female
- Genotype
- Humans
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive
- Leukocyte Count