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Article

AML1 mutations induced MDS and MDS/AML in a mouse BMT model.

Blood - 15 Apr 2008

Watanabe-Okochi Naoko, Kitaura Jiro, Ono Ryoichi, Harada Hironori, Harada Yuka, Komeno Yukiko, Nakajima Hideaki, Nosaka Tetsuya, Inaba Toshiya, Kitamura Toshio

Abstract excerpt

Myelodysplastic syndrome (MDS) is a hematopoietic stem-cell disorder characterized by trilineage dysplasia and susceptibility to acute myelogenous leukemia (AML). Analysis of molecular basis of MDS has been hampered by the heterogeneity of the disease. Recently, mutations of the transcription factor AML1/RUNX1 have been identified in 15% to 40% of MDS-refractory anemia with excess of blasts (RAEB) and MDS/AML. We...

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Source

Identifiers

PMID: 18192504
DOI: 10.1182/blood-2007-01-068346

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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