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Article

Genomic structure, transcriptional control, and tissue distribution of<i>HERG1</i>and<i>KCNQ1</i>genes

12 Jan 2008

Abstract excerpt

The long QT syndrome genes human ether-a-go-go-related gene (HERG1) and voltage-gated K+ channel, KQT-like subfamily, member 1, gene (KCNQ1), encoding K+ channels critical to the repolarization rate and repolarization reserve in cardiac cells, and thereby the likelihood of arrhythmias, are both composed of two isoforms: HERG1a and HERG1b and KCNQ1a and KCNQ1b, respectively. Expression of these genes is dynamic,...

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PMID: 18192214
DOI: 10.1152/ajpheart.01026.2007

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