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Article

Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1.

Genomics - 1 Jul 1998

Splawski I, Shen J, Timothy K W, Vincent G M, Lehmann M H, Keating M T

Abstract excerpt

Long QT syndrome (LQT) is a cardiac disorder causing syncope and sudden death from arrhythmias. LQT is characterized by prolongation of the QT interval on electrocardiogram, an indicationof abnormal cardiac repolarization. Mutations in KVLQT1, HERG, SCN5A, and KCNE1, genes encoding cardiac ion channels, cause LQT. Here, we define thecomplete genomic structure of three LQT genesand use this information to identify...

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Identifiers

PMID: 9693036
DOI: 10.1006/geno.1998.5361

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