Article
Genomic structure of three long QT syndrome genes: KVLQT1, HERG, and KCNE1.
Genomics - 1 Jul 1998
Splawski I, Shen J, Timothy K W, Vincent G M, Lehmann M H, Keating M T
Abstract excerpt
Long QT syndrome (LQT) is a cardiac disorder causing syncope and sudden death from arrhythmias. LQT is characterized by prolongation of the QT interval on electrocardiogram, an indicationof abnormal cardiac repolarization. Mutations in KVLQT1, HERG, SCN5A, and KCNE1, genes encoding cardiac ion ch...
Topics
- Alternative Splicing
- Amino Acid Sequence
- Base Sequence
- Cation Transport Proteins
- Chromosome Mapping
- DNA Mutational Analysis
- DNA Primers
- DNA-Binding Proteins
- ERG1 Potassium Channel
- Ether-A-Go-Go Potassium Channels
- Exons
- Female
- Humans
- Introns
- KCNQ Potassium Channels
- KCNQ1 Potassium Channel
- Long QT Syndrome
- Male