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Article

Prognostic significance of FLT3 internal tandem duplication and NPM1 mutations in acute myeloid leukemia in an unselected patient population.

International journal of hematology - 1 Dec 2007

Suzuki Rikio, Onizuka Makoto, Kojima Minoru, Shimada Masako, Okamura Kaori, Fukagawa Satomi, Tsuboi Kosuke, Kikuchi Ako, Kobayashi Hiroyuki, Shintani Ayumi, Ogawa Yoshiaki, Kawada Hiroshi, Hotta Tomomitsu, Ando Kiyoshi

Abstract excerpt

Mutations in the fms-like tyrosine kinase 3 (FLT3) gene containing an internal tandem duplication (FLT3/ITD) or mutations in the nucleophosmin 1 gene (NPM1) are thought to be prognostic indicators in acute myeloid leukemia (AML). Previous studies suggested that FLT3/ITD mutation indicates a poor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18192111
DOI: 10.1007/BF02984000

Genes

NPM1
FLT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-18192111-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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