Article

A 3D iPSC retina model reveals non-cell-autonomous and non-neuronal mechanism of photoreceptor degeneration in a lysosomal storage disorder

2025-07-15

Abstract excerpt

<h4>ABSTRACT</h4> Disruption of photoreceptor-retinal pigment epithelium (RPE) interface with loss of photoreceptor outer segments (POSs) in the retina is a pathological hallmark of several neurodegenerative and retinal diseases including lysosomal storage disorder’s like CLN3 disease. However, the retina is a functional composite in vivo; and in vitro stem cell models of retina that enable investigation of the...

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Literature Corpus work: 6fa951eb-ace5-534f-b664-e8b7a0692217
DOI: 10.1101/2025.07.10.664233

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