High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinoma.

doi:10.1200/JCO.2007.13.2043

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Article

High viral load and hepatitis B virus subgenotype ce are associated with increased risk of hepatocellular carcinoma.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Jan 2008

Chan Henry Lik-Yuen, Tse Chi-Hang, Mo Frankie, Koh Jane, Wong Vincent Wai-Sun, Wong Grace Lai-Hung, Lam Chan Stephen, Yeo Winnie, Sung Joseph Jao-Yiu, Mok Tony Shu-Kam

Abstract excerpt

PURPOSE: We aimed to investigate the impact of hepatitis B virus (HBV) DNA and HBV genotypes/subgenotypes on the risk of hepatocellular carcinoma (HCC). PATIENTS AND METHODS: A prospective cohort of patients infected with chronic HBV in a surveillance program for HCC since 1997 was studied. Ultrasound and alpha-fetoprotein evaluation were regularly performed to detect HCC. Risk factors for HCC and the...

Topics

Adult
Carcinoma, Hepatocellular
Chi-Square Distribution
Female
Genotype
Hepatitis B virus
Hepatitis B, Chronic
Hong Kong
Humans
Liver Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

Population Surveillance

Proportional Hazards Models

Prospective Studies

Risk Factors

Statistics, Nonparametric

Viral Load

Source

Open in PubMed

Identifiers

PMID: 18182659
DOI: 10.1200/JCO.2007.13.2043

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-18182659-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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