Article
Hepatitis B virus subgenotype C2- and B2-associated mutation patterns may be responsible for liver cirrhosis and hepatocellular carcinoma, respectively.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jul 2013
Chen Y M, Wu S H, Qiu C N, Yu D J, Wang X J
Abstract excerpt
The objective of this study was to examine hepatitis B virus (HBV) subgenotypes and mutations in enhancer II, basal core promoter, and precore regions of HBV in relation to risks of liver cirrhosis (LC) and hepatocellular carcinoma (HCC) in Southeast China. A case-control study was performed, including chronic hepatitis B (CHB; n=125), LC (n=120), and HCC (n=136). HBV was genotyped by multiplex polymerase chain...
Topics
- Adult
- Aged
- Alanine Transaminase
- Bilirubin
- Carcinoma, Hepatocellular
- Case-Control Studies
- Chi-Square Distribution
- China
- Female
- Genotype
- Hepatitis B Core Antigens