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Article

Activation of the unfolded protein response is associated with favorable prognosis in acute myeloid leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2009

Schardt Julian A, Weber Daniel, Eyholzer Marianne, Mueller Beatrice U, Pabst Thomas

Abstract excerpt

PURPOSE: The unfolded protein response is triggered by the accumulation of misfolded proteins within the endoplasmic reticulum. Previous studies suggest that the unfolded protein response is activated in some cancer cell lines and involved in tumor development. The role of the unfolded protein response during leukemogenesis is unknown thus far. EXPERIMENTAL DESIGN: Here, we assessed the induction of key effectors...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endoplasmic Reticulum Chaperone BiP

Share to Gene Expression Regulation, Leukemic

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Source

Identifiers

PMID: 19470730
DOI: 10.1158/1078-0432.CCR-08-2870

Genes

FLT3
XBP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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