Article
Relationship between antibiotic use and incidence of MexXY-OprM overproducers among clinical isolates of Pseudomonas aeruginosa.
Antimicrobial agents and chemotherapy - 1 Mar 2008
Hocquet Didier, Muller Arno, Blanc Karine, Plésiat Patrick, Talon Daniel, Monnet Dominique Louis, Bertrand Xavier
Abstract excerpt
In a university hospital, time-series analysis revealed a significant relationship between antibiotic (aminoglycoside, fluoroquinolone, and cefepime) use and incidence of MexXY-OprM-overproducing Pseudomonas aeruginosa. In vitro experiments confirm that such mutants were readily selected from both PAO1 and clinical strains when grown in the presence of these antibiotics.
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