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Article

Involvement of the MexXY-OprM efflux system in emergence of cefepime resistance in clinical strains of Pseudomonas aeruginosa.

Antimicrobial agents and chemotherapy - 1 Apr 2006

Hocquet Didier, Nordmann Patrice, El Garch Farid, Cabanne Ludovic, Plésiat Patrick

Abstract excerpt

Cefepime (FEP) and ceftazidime (CAZ) are potent beta-lactam antibiotics with similar MICs (1 to 2 mug/ml) for wild-type strains of Pseudomonas aeruginosa. However, recent epidemiological studies have highlighted the occurrence of isolates more resistant to FEP than to CAZ (FEPr/CAZs profile). We thus investigated the mechanisms conferring such a phenotype in 38 clonally unrelated strains collected in two French...

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Identifiers

PMID: 16569851
DOI: 10.1128/AAC.50.4.1347-1351.2006
PMCID: PMC1426951

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Source receipt: pubmed, retrieved 7 Sept 2026.

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