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Article

Inability to process and store proinsulin in transdifferentiated pancreatic acinar cells lacking the regulated secretory pathway.

The Journal of endocrinology - 1 Jan 2008

Aldibbiat A, Alidibbiat A, Marriott C E, Scougall K T, Campbell S C, Huang G C, Macfarlane W M, Shaw J A M

Abstract excerpt

Generation of new beta-cells from the adult pancreas or the embryonic stem cells is being pursued by research groups worldwide. Success will be dependent on confirmation of true beta-cell phenotype evidenced by capacity to process and store proinsulin. The aim of these studies was to robustly determine endocrine characteristics of the AR42J rat pancreatic acinar cell line before and after in vitro...

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Source

Identifiers

PMID: 18180315
DOI: 10.1677/JOE-07-0397

Genes

PDX1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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