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Article

In vitro transdifferentiation of hepatoma cells into functional pancreatic cells.

Mechanisms of development - 1 Jun 2005

Li Wan-Chun, Horb Marko E, Tosh David, Slack Jonathan M W

Abstract excerpt

We have characterised the transdifferentiation of human HepG2 (hepatoma) cells to pancreatic cells following introduction of an activated version of the pancreatic transcription factor Pdx1 (XlHbox8-VP16). The following questions are addressed: (1) are all types of pancreatic cells produced? (2) is the requirement for expression of the transgene temporary or permanent? (3) are the transdifferentiated beta-cells...

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Identifiers

PMID: 15939230
DOI: 10.1016/j.mod.2005.01.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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