Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization.

Journal of immunology (Baltimore, Md. : 1950) - 15 Jan 2008

Lau Christine, Wang Xiaomin, Song Lihua, North Michelle, Wiehler Shahina, Proud David, Chow Chung-Wai

Abstract excerpt

Human rhinovirus (HRV) causes the common cold. The most common acute infection in humans, HRV is a leading cause of exacerbations of asthma and chronic obstruction pulmonary disease because of its ability to exacerbate airway inflammation by altering epithelial cell biology upon binding to its receptor, ICAM-1. ICAM-1 regulates not only viral entry and replication but also signaling pathways that lead to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bronchi
Share to Clathrin

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endocytosis

Share to Intercellular Adhesion Molecule-1

Share to Proto-Oncogene Proteins c-akt

Share to Rhinovirus

Share to Syk Kinase

Share to Virus Internalization

Source

Identifiers

PMID: 18178826
DOI: 10.4049/jimmunol.180.2.870

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Syk associates with clathrin and mediates phosphatidylinositol 3-kinase activation during human rhinovirus internalization.PMID 18178826Read ↗

The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection.Semantic proximity Read ↗

Distinct roles for the linker region tyrosines of Syk in FcepsilonRI signaling in primary mast cells.Semantic proximity Read ↗

Epidermal Growth Factor Receptor Signaling to Erk1/2 and STATs Control the Intensity of the Epithelial Inflammatory Responses to Rhinovirus InfectionSemantic proximity Read ↗

Formation of rhinovirus-soluble ICAM-1 complexes and conformational changes in the virion.Semantic proximity Read ↗

Live cell imaging of interleukin-6-induced targeting of "transcription factor" STAT3 to sequestering endosomes in the cytoplasm.Semantic proximity Read ↗

WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation.Semantic proximity Read ↗

Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo.Semantic proximity Read ↗

Discrimination among rhinovirus serotypes for a variant ICAM-1 receptor molecule.Semantic proximity Read ↗

Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.Semantic proximity Read ↗

The Role of p38 MAPK in Rhinovirus-Induced Monocyte Chemoattractant Protein-1 Production by Monocytic-Lineage CellsSemantic proximity Read ↗

Src kinase has a central role in in vitro cellular internalization of Staphylococcus aureus.Semantic proximity Read ↗

Impairing the function of MLCK, myosin Va or myosin Vb disrupts Rhinovirus B14 replicationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.