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Article

MCPIP1 ribonuclease exhibits broad-spectrum antiviral effects through viral RNA binding and degradation

25 Jan 2013

Abstract excerpt

Monocyte chemoattractant protein 1-induced protein 1 (MCPIP1), belonging to the MCPIP family with highly conserved CCCH-type zinc finger and Nedd4-BP1, YacP Nuclease domains, has been implicated in negative regulation of the cellular inflammatory responses. In this report, we demonstrate for the first time that this RNA-binding nuclease also targets viral RNA and possesses potent antiviral activities....

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PMID: 23355615
DOI: 10.1093/nar/gkt019

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